Fenofibrate in conjunction with rosuvastatin calcium is used in in the treatment of hypercholesterolemia and hypertriglyceridemia. A simple, accurate, precise and cost effective first order derivative UV spectrophotometric method has been developed for determination of Rosuvastatin calcium (ROS) and Fenofibrate (FEN) in tablet dosage form. The Beer-Lambert‘s law was obeyed in the concentration range 4-12 µg/ml and 16-48 µg/ml for ROS and FEN, respectively. The proposed method was validated and successfully applied to the determination of ROS and FEN in tablet formulations. The results suggested that proposed method can be used for routine quality control of tablets containing ROS and FEN.
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